- Prof. Marcello Iriti
- Department of Biomedical, Surgical and Dental Sciences, Milan State University, Milan, Italy.
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Special Issue Introduction
The One Health paradigm claims that the health of humans is connected to the health of animals, plants, and the environment. Indeed, an estimated 60% of human pathogens originate in animals, about three-quarters of which are of wildlife origin. This holistic vision implies a coordinated, collaborative, multidisciplinary, and cross-sectoral approach to tackle threats that can originate at the environment–plant–animal–human interface while protecting biodiversity. However, the use of antibiotics is associated with the increase in antimicrobial resistance of pathogens that can affect the efficiency of conventional drugs. This scenario made it necessary to search for alternative therapeutic approaches. Medicinal plants, with their consolidated history, represent an excellent resource of natural products used as an alternative therapy, representing an essential component of traditional medicines. Therefore, the use of plant extracts and essential oils can be a promising alternative for the control of infectious diseases. Natural products can be developed as novel multitarget antimicrobial agents capable of interacting with many molecular and physiological microbial targets. Furthermore, the combination of natural plant products (plant extracts, phytochemicals, or essential oils) with conventional antimicrobials offers another field of application and should be widely pursued as a therapeutic approach capable of sensitizing resistant pathogens and contributing to limiting the antimicrobial resistance pandemics and the global burden of infectious diseases. In this view, natural products can be developed as adjuvant and sensitizing agents in association with conventional antibiotic therapies to improve their efficacy, decrease their adverse effects, reduce the risk of selecting resistant microbial strains, or even reverse resistance. Finally, plant extracts and essential oils are often considered safe for animals, humans, and the environment.
Infectious diseases, one health, animal wellness, zoonoses, phytotherapeutics, herbal remedies, plant extracts, essential oils, antimicrobial resistance, multidrug resistance, ethnopharmacology, global climate change
Submission Deadline31 Mar 2023